Pharmacology of Heart failure



 Introduction  : Heart failure is a functional and structural disorder that impair the heart from carrying out it's function as a pump to carry out physiological circulation.... 

 

 Causes :

 1. Reduced Ventricular contractility

Myocardial infarction

Myocarditis

Cardiomyopathy

 2. Ventricular Outflow obstruction(pressure overload)

 A. Left heart failure

Hypertension (HTN)

Aortic stenosis

B. Right heart failure

Pulmonary HTN

Pulmonary valve stenosis

3. Ventricular inflow obstruction 

Mitral Stenosis

Endomyocardial fibrosis

Tricuspid Stenosis

Constrictive pericarditis

4. Ventricular Volume Overload

Mitral regurgitation

Pulmonary regurgitation

Increase metabolic demand

Ventricular Septal defect

Atrial Septal defect


 Factors increasing or Reducing heart failure

Anemia

Thyrotoxicosis

Pulmonary embolism

Infective endocarditis

Myocardial infarction

Drugs e.g beta adrenoceptor antagonist

Obesity

Pregnancy

Arrhythmia

Pulmonary infection

Pathophysiology

Heart failure results from complex neurohormonal changes, renin,agiotenesin, aldosterone axis and sympathetic nervous system.

Initially these changes help the heart to optimize cardiac function by altering the preload and afterload and by increasing myocardial contractility....

However, they become counterproductive and cause reduction in cardiac output by causing increasing peripheral vascular resistance...


Investigation

FBC

Chest x-ray

Electrocardiogram

Echocardiography


 Clinical features

Left side : dyspnea, orthopnea, chest pain, PND, 

Right side: pedal edema, hepatic congestion, ascites

  

 Drug used for treatment

1. Positive ionotropic drugs

a. _Digitalis_

Digoxin

Digitoxin

 b. _Beta adrenoceptor stimulant_

Dopamine

Dobutamine

c.  _Bipyridines_

Inamirinone

Milrinine


2. Negative ionotropic drugs

Ace inhibitors

Diuretics

Vasodilators

Beta adrenoceptor blockers...

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